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That means while the condition is severe, it happens rarely, and the overall risk for any individual remains low

The new treatments hold much promise for people whose health is seriously compromised by too much weight but that promise must be discounted against the high cost of the drugs, medical risks, and petabytes of research data that show how fleeting weight loss can be

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In the central nervous system, semaglutide activates GLP-1 receptors in hypothalamic regions that regulate appetite, increasing feelings of satiety and reducing hunger, which leads to lower calorie intake and sustained weight loss

10.6118/jmm.2015.21.2.93 [DOI] [PMC free article] [PubMed] [Google Scholar] Li Y., Fu H., Wang H., Luo S., Wang L., Chen J., et al