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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Powe C.E., Evans M.K., Wenger J., Zonderman A.B., Berg A.H., Nalls M., Tamez H., Zhang D., Bhan I., Karumanchi S.A., et al

D DOX and D CCMH are the concentrations of DOX and CCMH corresponding to the IC50 of DCCMH combination therapy

Moreover, it is employed in the preservation of protein-dithiols by the protein disulfide reductase (glutathione) (EC 1.8.4.2), an enzyme that catalyzes the chemical reaction: This enzyme acts on different substrates, such as insulin, which is inactivated by cleavage of the disulfide bridge, or on protein disulfide, in which the reduction to protein-dithiol restores the catalytic activity, protecting the cell from oxidant stress

10.1002/da.22169 Depress

Dermatol Res Pract

(2020) found that ferroptosis inducer Ras-selective lethal small molecule 3 treatment exacerbated the disease symptom, including hepatic steatosis and inflammation, which could be restored by the intervention of ferroptosis inhibitors