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Effects on caloric intake and body weight Decreased calorie intake due to increased satiety and decreased appetite Decreased body weight , with more fat loss than lean mass loss) 2

These effects were blunted in CNS-specific GIPR knockout mice, suggesting a key role of CNS GIPR in the control of energy metabolism (138) ( Figure 1 Section C)

The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes

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results showing that oral GLP-1 agonist orforglipron significantly reduced A1C at all doses and induced weight loss at 12 mg and 36 mg versus placebo, with a safety profile consistent with the GLP-1 class