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Patient selection for the 10mg dose should encompass glycemic status and prior response to 5mg, weight loss targets, renal function, cardiovascular risk profile, retinopathy status, history of pancreatitis or gallbladder disease, and the patients experience of gastrointestinal adverse reactions during prior escalation steps

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Clinical Evidence Behind Approval The FDAs decision to approve Zepbound was based on two large, randomized, double-blind, placebo-controlled studies involving adults with moderate to severe OSA

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The additional glucagon receptor activation introduces another variable that could influence neurological effects in either direction

Clinical outcomes of tirzepatide or GLP-1 receptor agonists in individuals with type 2 diabetes