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Med Hypotheses 2018;113:91-7
In vitro studies in N2a cells showed that ApoE4 fragments (aa 1272) interact with mitochondria and cause mitochondrial dysfunction and neurotoxicity (Chang et al., 2005)
Protein misfolding in the endoplasmic reticulum as a conduit to human disease
These substances have the capacity to penetrate the epidermal layer via the appendages of the skin
Not only is high-dose VitC known to relieve pain in cancer patients [79], vast clinical evidence suggests that it has a significant positive impact on patients well-being [14, 1719, 63, 8083]
Z.ZhaoY.et al (2013)
