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Some patients begin with one medication and add the second later if they hit a plateau, need stronger appetite control, or would benefit from a different mechanism
Excessive BDNF signaling has been associated with epileptiform activity in some research models
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Nicergoline induced vasodilation and increased cerebral blood flow [69]
Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF
