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10.1155/2022/1225578 [DOI] [PMC free article] [PubMed] [Google Scholar] de la Prez JM, Andrs-Juan C, Plou FJ, Prez-Lebea E (2021) Impact of Zinc, Glutathione, and polyphenols as antioxidants in the immune response against SARS-CoV-2

Key Research Highlights: IGF-1 brain penetration and neuroprotective signaling documented in preclinical models Cognitive improvements in GH-deficient animal models following IGF-1 restoration Neuropeptide Y modulation by Ipamorelin provides tool for studying stress and pain pathways GH receptor expression in brain tissue establishes direct neurological targets for secretagogue research Wound Healing and Tissue Repair Research GH and IGF-1 both promote tissue repair processes, and secretagogue-driven elevation of these signals is studied in wound healing and recovery models

Characterization of in vitro growth of multiple myeloma cells

In the case of metabolic diseases, elevated levels IGFBP-3 could increase risk of T2DM independently of IGF-1 [10]

Additionally, five studies have examined the link between circulating IGF-2 levels and the association with CRPCLs

[DOI] [PMC free article] [PubMed] [Google Scholar] 141.Lai S.W.T., Gonzalez E.D.J.L., Zoukari T., Ki P., Shuck S.C