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Increased adiposity, which plays a central role in both aging and obesity-related pathologies, is responsible for enhanced oxidative stress and chronic low-grade inflammatory responses by promoting free radical production and the release of pro-inflammatory cytokines

This action is directly linked to increased insulin secretion and suppression of glucagon

However, a judge recently denied an initial injunction to allow compounding pharmacies to continue making the drugs

The SURPASS-CVOT trial is an ongoing phase 3 cardiovascular outcomes trial designed to evaluate the non-inferiority and potential superiority of tirzepatide compared to dulaglutide in cardiovascular outcomes [88,89]

5 Fu, Z., Gong, L., Liu, J., Wu, J., Barrett, E

Dipeptidyl peptidase-4 inhibitors and risk of heart failure in type 2 diabetes: systematic review and meta-analysis of randomised and observational studies