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Under normal conditions, there is a well-regulated equilibrium in the GI mucosa between inflammatory cytokines (such as TNF-, IL-1, IL-6, IL-8, IL-17, and IL-23) and anti-inflammatory cytokines (like IL-5, IL-10, IL-11, and TGF-) (75)

Although a single treatment study has been reported that BTX is effective in pain relief and that PPS helps improve subjective symptoms in patients [23, 24], the strength of the current NMA is that a de novo combination of therapy is proposed

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