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The process for synthesizing (S)-SFN involves the following steps: Reaction of (+)-(1S,2R)-trans-2-phenylcyclohexyl(S)-methanesulfinate with a Grignard reagent derived from 4-chlorobutyl tert-butyldimethylsilyl ether

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98 Recently, inhibition of DJ-1 (also known as PARK7-parkinsonism-associated deglycase) has been shown to enhance the sensitivity of tumor cells to ferroptosis induced by sorafenib and evaluated the antitumor activity of erastin in a xenograft nude mouse model via inhibition of the transsulfuration pathway and limiting the supply of cysteine

PMID: 33567185 | doi:10.1056/NEJMoa2032183 Enebo LB et al

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