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The overall EORTC-QLQ-CIPN20 sensory subscale did not significantly change between minocycline and placebo, despite the decrease in P-APS linked to minocycline usage [48]
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Hakobyan N, Kazarian T, Jabbar AA, Jabbar KJ, Valentino LA

Most people feel a noticeable energy boost within 24 to 72 hours, especially if they were deficient