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It should not be used in patients with a history of acute pancreatitis or in those with type 1 diabetes
A group of researchers analyzed MRI, histology, and harmonic dose data to determine that the use of microbubbles and focused ultrasound was safe for opening the blood-brain barrier (BBB) in patients with infiltrating gliomas

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Its pharmacokinetics are influenced by factors such as renal function, genetics, sex, and age
