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Description
Interestingly, this modulation only occurs when the channel is activated by osmotic changes, but not by temperature (Fernandes et al., 2008)

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Effect of Zhikuoning mixture on expression of TNF- in human bronchial epithelial cells in vitro study
Plant Physiol 132:16311641 Pignocchi C, Kiddle G, Hernndez I, Foster SJ, Asensi A, Taybi T, Barnes J, Foyer CH (2006) Ascorbate oxidase-dependent changes in the redox state of the apoplast modulate gene transcript accumulation leading to modified hormone signaling and orchestration of defense processes in tobacco

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To mitigate oxidation, raw materials must be free of reactive impurities such as transition metal ions and peroxides [159]
