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this was usually achieved by replacing alanine in the second position with another amino acid other than proline

Albiglutide is generated from a genetic fusion of two modified recombinant GLP-1 (736) molecules linked in tandem to recombinant human albumin (90), while dulaglutide is created by conjugating two GLP-1 (737) analogues to the Fc fragment of a modified monoclonal antibody (IgG4) via peptide ((Gly 4 Ser) 3 Ala) linker (91)

In summary, a simple approach to modify and modulate the properties of bioactive peptide helices using small foldamer inserts was developed

Graphical Abstract Access this article Similar content being viewed by others Data Availability As this study is a meta-analysis, the data analyzed in this work were obtained from previously published sources

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