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1) Though berberine may contribute to a small amount of weight loss for some people, studies are limited and often include people who were making other dietary and lifestyle changes at the same time

Its effects on blood sugar for diabetes are comparable to currently available GLP-1 drugs like Ozempic

Diabetes Obes Metab (2014) 16:2735

The weight loss and improved insulin sensitivity from Retatrutide address underlying causes of glucose dysregulation

Methotrexate is teratogenic (harmful to a developing foetus) and must be avoided during pregnancy and breastfeeding

The increase in hypoglycemic therapies with a favorable cardiovascular profile has revolutionized the treatment of T2D and the main drawback is the high cost associated with newer therapies