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Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity

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However, in a LIVE sub-study, myocardial glucose utilization did not improve in the liraglutide group as examined by F-fluorodeoxyglucose positron emission tomography [41], similar to a study using albiglutide [42]

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Because calorie intake ultimately drives changes in body composition, even modest appetite modulation could influence weight trends

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