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This can be due to the absence of a tyrosine residue at the corresponding position (Y2518 in SMRT or Y1 in CTD) that interacts with SHARP R3566 via - interactions and forms hydrophobic contacts with M3553

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Long-term consequences of NNMT inhibition are unknown Dosing is not established : No human dosing protocol has been validated

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Weeks three and four mark the stabilization phase

Zhu and He, 2024)