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Indeed, weve seen an explosion of potential treatments (oxaloacetate, Rapamycin, nicotine patch, metformin, methylene blue, Abilify, stellate ganglion blocks, plasmapheresis, checkpoint inhibitors, Jak-Stat inhibitors, monoclonal antibodies, neuroplasticity approaches, etc.) since the advent of long COVID

In this process, the expression of orexigenic POMC is upregulated, whereas the anorexigenic AgRP and NPY are repressed, leading to reduced food intake and increased energy expenditure [91], [92], [93]

The problem is that many people who take such drugs quit them within two years because of side effects and the cost

Chronic fatigue syndrome (also called myalgic encephalomyelitis, or ME/CFS) is a distinct medical condition with its own pathophysiology

doi: 10.1111/acel.12932 65 ButterfieldDAHalliwellB

Microdosing Approach: Suitable for individuals with high sensitivity to medications