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IL-1Ra acts as a counterbalance to IL-1beta, mitigating its inflammatory actions and promoting a more balanced immune response ( 2.3.2.3 Systemic vasculitis Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) are associated with antineutrophil cytoplasmic antibodies (ANCA)

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