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The mechanism has been suggested to involve inhibition of cardiac intracellular signaling pathways (Ca 2+ /calmodulin-dependent protein kinase II and protein kinase C) due to saxagliptin-mediated inhibition DPP-9 (136)

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In patients with T2DM and chronic liver disease attributed to MASLD, the risk of major adverse liver outcomes after GLP-1RA treatment over 10 years fails to decrease (15.8% vs