pioneer 5 semaglutide Efficacy and safety of oral monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes (PIONEER 11): a double-blind, Phase IIIa, randomised trial | Diabetologia Latest Clinical Journal | Reviews

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In patients with T2DM, the reduction in HbA1c is not overtly different between twice daily or once daily administration of lixisenatide [892]

Tirzepatide (Mounjaro for diabetes and Zepbound for obesity, both Eli Lilly), a dual GLP-1/GIP agonist titrated gradually across a broad dosing range, showed a favorable safety profile, with GIP agonism probably buffering GLP-1-mediated fluid shifts, stabilizing vascular tone and reducing ischemic vulnerability