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Developed by Eli Lilly, retatrutide is currently in Phase 3 clinical trials for obesity and type 2 diabetes

Next step: larger, well-powered trials in knee OA that prioritize patient-centered outcomes (pain, function, imaging, and time to joint replacement), plus equitable access so these benefits are not limited to the few

Nine studies reported changes in body weight, with the most substantial reductions observed in comparisons against placebo

This approval marks the first FDA-approved oral GLP-1 weight loss pill , which is expected to significantly influence demand in 2026

Compounded semaglutide injections start at $149 per month with PlexusDx, with no hidden fees, membership costs, or insurance requirements

However, its crucial to remember that semaglutide is not intended for long-term use and should not be seen as a permanent weight management solution