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10.1038/s41392-021-00648-7 49 HuangY.WangL.ChengZ.YangB.YuJ.ChenY.et al (2021)

Hepatology 47(5):14951503 Li X, Zhang W, Cao Q, Wang Z, Zhao M, Xu L, Zhuang Q (2020) Mitochondrial dysfunction in fibrotic diseases

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Furthermore, secreted apolipoprotein E (ApoE) from melanoma cells modulates ferroptosis sensitivity by decreasing peroxidation-prone PUFA content and enhancing GPX4 levels, contributing to ferroptosis resistance and correlating with poor patient prognosis ( Tumor suppressor genes such as p53 and BAP1 also intricately regulate ferroptosis sensitivity in melanoma

The IC 50 values of the extract showed that its primary antioxidant mechanism is ferric ion chelation potential