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Many patients begin seeing results within the first month of treatment, with significant progress typically noticed within 2-3 months

Once metabolically stable, it may be possible to taper or discontinue insulin and replace it with other agents, as required [Grade D, Consensus]

For example, FTO carriers may benefit from structured meal timing and higher protein to overcome genetic appetite bias, while others show stronger response to lower-carb approaches

[DOI] [PMC free article] [PubMed] [Google Scholar] 1138.Ratner RE, Hirsch IB, Neifing JL, Garg SK, Mecca TE, Wilson CA

Given these practical constraints, clinicians, formulary decision-makers, and payers should use a patient-centered approach, balancing efficacy, costs, patient preferences, and safety considerations when selecting obesity pharmacotherapy

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