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GLP-1R agonists show great potential in AD, but key challenges, such as blood brain barrier (BBB) penetration, clinical trial inconsistency, long-term safety and precision therapy, need to be addressed

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Upon agonist binding, the GPCR undergoes a conformational change and transmits extracellular signals through heterotrimeric G-proteins, which consist of G and G subunits [105]

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