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Fatigue is another consideration at higher doses

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The shared molecular binding of the brains vitamin B12 carrier protein, known as transcobalamin 2 or TCN2, with the FDA-approved MS drug fingolimod, provides a mechanistic link between B12 signaling and MS, towards reducing neuroinflammation and possibly neurodegeneration, said Chun, a professor in the Center for Genetic Disorders and Aging Research at Sanford Burnham Prebys