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By contrast, GAT3 protein levels at P5 do not differ between SMA and control mice, consistent with the physiological immaturity of the GABAergic system at this stage: PV interneurons have not yet reached full maturation, GAD enzyme levels remain unchanged, and the developmental GABA switch from excitatory to inhibitory has not occurred

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The new study, also initiated by Nasca, recruited 20- to 70-year-old men and women who had been diagnosed with depression and, amid episodes of acute depression, had been admitted to either Weill Cornell Medicine or Mount Sinai School of Medicine, both in New York City, for treatment

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