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The lapse went largely unnoticed until it was recently highlighted by Derek Lowe in Science, where he described it as an eyebrow-raising moment for a company with so much at stake

This lack of human clinical research is not an oversight

Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

This dual action appears to produce greater weight loss effects, though it may also come with different side effect patterns

Semaglutide also demonstrates strong efficacy while maintaining a favorable safety and tolerability profile

So, is Ozempic marketed as a medication to improve insulin resistance