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In STEP 1 and SURMOUNT-1, semaglutide and tirzepatide produced large, durable reductions in body weight, setting a new efficacy benchmark for pharmacotherapy [1,2]

Fiber and hydration support digestion and help offset the GI discomfort that can accompany reduced food intake

Thats why participants in my free 30-Day PCOS Diet Challenge see amazing changes within a few weeks of following my PCOS meal plans

Variants in genes like FTO rs9939609 and MC4R rs17782313 can affect how strongly an individual's brain responds to reward signalsa factor that may influence both overeating and nicotine dependence

Similarly, in rats injected with monoclonal antibodies (mAbs) in the hippocampus, pre-treatment with liraglutide significantly protected from the mAbs-induced damage of spatial memory and long-term potentiation (51)

Beyond their metabolic effects, GLP-1RAs act on mesolimbic, hypothalamic, and brainstem circuits to influence reinforcement, craving, withdrawal, and relapse