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CpG island methylator phenotype in colorectal cancer
Teh JLF, Cheng PF, Purwin TJ, et al
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The central regulator of the ARE is the transcription factor Nrf2, which is retained in inactive form in the cytoplasmic compartment by binding to a cysteine-rich protein, Keap1
doi: 10.1016/j.ccm.2020.06.007 35 TanDBAmranFSTeoTHPricePMoodleyYP
The histopathological hallmarks of ALD include steatosis, hepatocyte ballooning, and neutrophil infiltration (Stickel et al., 2017), mirrored biochemically by elevated serum transaminases, dyslipidemia, diminished antioxidant enzyme activities, and increased pro-inflammatory cytokines (Li et al., 2025)
