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Firstly, complexed flavonoids are more soluble in water-based creams and gels, allowing formulations with higher active ingredient content without visible precipitation [108]

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Interleukin-6 and ARDS Progression to ARDS in a subset of COVID-19 patients can be partially attributed to dysregulation of host cytokine production precipitating a positive feedback cycle of inflammatory insult and parenchymal injury

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Orphanet J Rare Dis 7 (2012): 10

They also reduce local irritation, resulting in increased patient compliance [142]