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The analyses included all randomized participants receiving at least one treatment dose (modified intent-to-treat (mITT) population), and all analyses were conducted using individual participant data in accordance with the intention-to-treat principle

Compared to Tirzepatide's dual GIP/GLP-1 mechanism achieving 20.2% weight loss at 72 weeks, Retatrutide's addition of glucagon receptor agonism appears to enhance energy expenditure and hepatic lipid metabolism

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