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Bina and Tonsor, 2025)

347 This was achieved by decreasing the expression of proinflammatory cytokines such as tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-8 (IL-8)

The HbA1c reduction of 2.02 percentage points at 12mg brought 67% of participants to normoglycemic levels (HbA1c below 5.7%)

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The body perceives famine and downregulates accordingly

These improvements include: Gastrointestinal Benefits: Reduced chronic diarrhea and abdominal cramping Improved tolerance to previously triggering foods Decreased bloating and digestive discomfort Better overall gut stability Systemic Improvements: Reduction in chronic fatigue and brain fog Decreased frequency and severity of flushing episodes Improved sleep quality and energy levels Better exercise tolerance without triggering flares Skin and Respiratory Changes: Fewer spontaneous hives and skin reactions Reduced respiratory symptoms and wheezing Less reactive responses to environmental triggers Improved overall symptom stability What particularly strikes me is the timing of these improvements