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IGF-1 drives hypertrophy through two complementary mechanisms: increased protein synthesis via the PI3K/Akt/mTOR pathway and satellite cell activation that adds new myonuclei to growing muscle fibers

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Recent insights include participation in the intrinsic environmental and developmental signalling pathways that regulate plant growth, development, and defence

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Wolever TM, Zurbau A, Koecher K, Au-Young F

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Using this strategy, Niu et al

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