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Deep HPA Axis Regulation: NASSAs enhance glucocorticoid receptor (GR) sensitivity by blocking 5-HT2A receptors, forming a dual mechanism with Retatrutide's HPA axis modulation to significantly improve refractory depressive symptoms
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A decline in MOTS-c levels associated with aging and diabetes has also been reported in various tissues, including skeletal muscle and circulation, by our group and others 6,7,8,9,10,111

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The potential for improving health outcomes in people with obesity and metabolic disease is enormous

Key outcomes (surgery vs GLP-1 medicines alone) Compared to medications, surgery offers: 32% lower risk of death (all-cause mortality) 35% lower risk of major cardiovascular events (heart attack, heart failure, stroke) 47% lower risk of serious kidney disease 54% lower risk of diabetes-related eye damage (retinopathy) Greater average 10-year weight loss: ~21.6% vs ~6.8% Bigger A1c reduction: 0.86% vs 0.23% Why Surgery Outperformed GLP-1s in the Real World Adherence: Whether or not youre in a study, if you have weight loss surgery, you are left with a permanent tool to help you lose weight and maintain that loss, providing you follow some basic rules
