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Some of the toxins in cigarette affect the mouth, throat and lungs, while others travel in the bloodstream throughout the body
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Its popularity reflects broader shifts in consumer preference, manufacturing hubs, and global distribution patterns
For example, DES induces gene expression of several oestrogen-responsive HOXA genes necessary for differentiation of human female reproductive tract cells, which is probably responsible for the metaplastic effects of DES 110,111
Helyar, John (1988)
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