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Prescribing GLP-1 drugs to treat adolescents with obesity involves some unique considerations, according to experts, including many unknowns about the potential long-term health impacts both positive and negative in patients so young. We dont know if theres a differential effect of starting the medication at a younger age versus an older age, said []

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Among the mechanisms, our research group and others have demonstrated that the gut microbiota fermentation (i.e., bacterial digestion of specific compounds) of specific prebiotics or other non-digestible carbohydrates is associated with the secretion of enteroendocrine peptides, such as the glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), produced by L-cells

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Mood changes during GLP-1 therapy are rare but worth understanding