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There is no pharmacological reason you cannot start both simultaneously

Both medications show similar efficacy patterns in non-diabetic versus diabetic populations when BMI and metabolic criteria are met

[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Sykes S, Morgan LM, English J, Marks V (1980) Evidence for preferential stimulation of gastric inhibitory polypeptide secretion in the rat by actively transported carbohydrates and their analogues

However, absorption limitations and lower bioavailability make traditional injections the evidence-backed choice for maximum weight loss results, with clinical trials showing injected GLP-1 receptor agonists produce 15-22% body weight reduction over 68 weeks