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It inhibits NF-?B activation and reduces inflammatory cytokines such as TNF-

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Highlighting this, near-infrared (NIR)-triggered NO production supressed the proteasomal degradation of HIF-1

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The above notion could reconcile the paradox of EBV exposure being a strict requirement for subsequent development of MS, and on the other hand the recent failure of an EBV-specific T-cell therapy ( The above hypothetical scenario could explain many paradoxes, the most puzzling being that on the one hand, prior EBV infection is required for the development of MS, yet on the other, presence of virus in the brain (assayed by conventional methods probing for viral nucleic acids) is not convincingly detected (Lassmann et al., 2011)