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First-line treatment for ED typically involves oral phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, tadalafil, vardenafil, and avanafil

Mller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschp MH

Microdosing does not independently protect muscle

PubMed PMID: 17928588

Adipose tissue produces estrogen through aromatase conversion

Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2/3a, randomised, controlled trial