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Based on this Unger argued that disruptions to the release of glucagon played an important role in the development of type 2 diabetes

[DOI] [PubMed] [Google Scholar] 149.Tucker J.D., Dhanvantari S., Brubaker P.L

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They found that for FDA approved GLP-1s for weight loss, liraglutide (Saxenda) and semaglutide (Wegovy), the percent of side effects reported was as follows: Nausea: 42.2% Diarrhea: 21.9% Vomiting: also 21.9% Constipation: 8.4% They report that although the incidence of side effects were similar among medications, semaglutide had the greatest risk of nausea, diarrhea, and vomiting, whereas liraglutide had the greatest risk of upper abdominal pain

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