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A modified FOXO4-p53 interfering peptide causes p53 nuclear exclusion, which can: Selectively induce apoptosis in senescent cells in vitro and in vivo Neutralize phenotypical and liver chemotoxicity by Doxorubicin Restore fitness, hair density and renal function in fast and naturally aged mice Acknowledgments We thank Felicity Chandler for assistance with IHC experiments, Anne Drabbe and David Brouwer for assistance with in vivo experiments, Yanto Ridwan for assistance with CT and IVIS imaging, Yvette van Loon for genotyping of the mice, Martin Viertler for initial NMR experiments, Boudewijn Burgering for fruitful discussions and Petra de Keizer-Burger for critical reading of the manuscript

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes

With their ability to deliver targeted treatments, serums offer a powerful solution for a variety of skin issues, making them an essential component of a comprehensive skincare regimen

These hormones require precise solutions to be effective, and bacteriostatic water fits the bill

It gives skin color or tone

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