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8 Gut microbiome Related Stories Semaglutide dose may matter more than weight loss for heart health GLP-1 exposure in pregnancy does not clearly raise major birth defect risk Nearly one in 10 Britons use or want weight-loss medication Probiotic strains, such as Akkermansia muciniphila and Lactobacillus species, have been linked to improvements in gut barrier function, systemic inflammation, and metabolic markers

Additionally, some IBS patientsparticularly those with IBS-C (constipation-predominant)may experience worsening of slow transit and constipation when starting GLP-1 medications, as these drugs naturally slow gastric emptying

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10.1056/NEJMoa1603827 [DOI] [PMC free article] [PubMed] [Google Scholar] 101.Pratley RE, Aroda VR, Lingvay I, Ludemann J, Andreassen C, Navarria A, et al

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