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In a phase 2, double-blind, placebo-controlled trial of retatrutide vs placebo (NCT04881760), adults with obesity or with overweight and obesity-related complications but without diabetes who were treated with retatrutide achieved a mean weight reduction of up to 17.5 % at 24 weeks (primary endpoint) and up to 24.2 % at 48 weeks in the 12 mg group

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Direct Anti-Fibrotic Mechanisms In considering the direct anti-fibrotic mechanisms, it is important to note that the expression of incretin receptors is not confined to the pancreatic islets

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