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The maximum approved dose is 15 mg once weekly, typically reached by week 20 or 21 of treatment

In the EMPA-REG study, empagliflozin significantly reduced the risk for the composite renal outcome, which included doubling of serum creatinine, progression of macroalbuminuria, initiation of renal replacement therapy, or renal death ( Subsequent studies, such as CREDENCE, DAPA-CKD, and EMPA-KIDNEY, were specifically designed to investigate the renoprotective effects of SGLT-2i

If you experience significant nausea or GI distress, we may pause titration for an extra week or extend the dose interval

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What we do know: Many women who were exposed early in pregnancy have had healthy babies The risk appears lower with early pregnancy exposure vs

Clinical Access & Oversight Okay Clinical oversight exists, but the details of the ongoing care model are not explained well before you sign up