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Subsequent pharmacology work has characterized tirzepatide as an imbalanced and biased dual agonist: at clinically efficacious amounts, the calculated receptor occupancy favors the GIP receptor, while at the GLP-1 receptor the compound shows signaling bias toward cyclic AMP with reduced receptor desensitization compared with native GLP-1

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Tirzepatide is a dual GIP/GLP-1 receptor agonist , meaning it activates two gut hormone receptors that help regulate appetite, digestion, and blood sugar