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In a rat model of SNL, intrathecal administration of exendin-4 significantly alleviated pain-induced hippocampal neuroinflammation and enhanced cognitive recovery [68]

For instance, a recent study illustrated that liraglutide effectively alleviated asthmatic airway inflammation via the suppression of NLRP3 inflammasome activation and IL-1 secretion in high-fat diet-induced obese asthmatic mice [21]

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Retatrutide vs semaglutide comparisons highlight the progression toward more potent multi-agonist approaches