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In contrast, the full (liposome-encapsulated) plasma level of ribavirin in EYPC-based liposomes (again after a single intravenous injection of 50 mg/kg in rats) was found to peak at only 1 millimolar and to rapidly decline (with a half-life of about 3 hours), with no observed difference between the 0 and 2% GSH on the outer surface of the liposomes
Billy Dunn, director of the Office of Neuroscience in the FDAs Center for Drug Evaluation and Research
Adjustments and Considerations for Dosage Dosage changes might be needed for each patient
10.1021/acsami.6b04933 25 CaiY.Van PuttenJ
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