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GLP-1 inhibits intestinal contractions through mechanisms that may involve the central nervous system via vagal pathways or direct action on central receptors [24], as well as the enteric nervous system by modulating neurotransmission through presynaptic receptors affecting nitric oxide release [25,26]

Patients who already had a history of irritable bowel syndrome or other gut sensitivities prior to starting treatment may find they are more susceptible to semaglutide diarrhea than those with no prior gastrointestinal history

Missing a single weekly dose typically results in a temporary dip in appetite suppression and may feel like your medication 'wore off,' but it does not undo your progress or require emergency medical intervention

Always verify your medication with your pharmacist or use official resources to ensure that you have the correct drug

Make sure the container has a reliable seal to prevent warm air from entering

For patients with obstructive sleep apnea and obesity, Zepbound is the first and only medication approved by the FDA specifically to treat OSA