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It reduced plasma alanine and glucagon levels, indicating indirect target engagement at GcgRs and GLP-1Rs [53]

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Skye is conducting a Phase 2a clinical trial ( ClinicalTrials.gov: NCT06577090 ) in obesity for nimacimab, a negative allosteric modulating antibody that peripherally inhibits CB1

doi: 10.2337/db15-1615 77 PllnenPMLempainenJLaineAPToppariJVeijolaRIlonenJet al

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That is not necessarily an indicator of quality, positive or negative
